Induction of coagulation cascades was already observed in the cancer context[63] and is associated with higher potential for metastasis formation and thromboembolism in patients.[64] Notably, another important protein enriched in 3D‐derived SC EVs is the tissue factor (TF), a crucial initiator of the coagulation process.[63] Interestingly, patients that have higher expression of these proteins demonstrated a decrease survival rate when compared to other clusters of patients. Here, TF is linked to cancer.