It has already been reported that the presence of complement proteins in secreted EVs.[66] It has been described that C3 and C5 (and their active forms, C3a and C5a), which are termed anaphylatoxins, are potent pro‐inflammatory molecules capable of reshaping the tumor microenvironment by enhancing tumor growth and metastatic potential.[67] Although no association was found between these proteins and patient survival, these results suggest that 3D‐derived EVs may hold greater potential to modulate the complement cascade to sustain cancer progression. Here, C5 is linked to cancer.