Currently, chemically induced EC animal models and GEMMs of EC are mostly used in vivo, and few of them can fully recapitulate the entire process of EC in patients.[12, 31] Based on GEMMs, the functions of Pten and Lkb1 as tumor suppressors have been identified.[12, 32] However, GEMMs are very costly and extremely time‐consuming, which limits their wide application. This evidence concerns the gene PTEN and neoplasm.