Despite cTnI and CK‐MB have been widely used as the main biomarker to distinguish UA and AMI; however, more recently, studies have revealed that cTnI and CK‐MB disruption may be associated with other disorders, such as tachy‐ or brady‐arrhythmias and renal failure, which are not specific to AMI.[6] At this point, developing a precise diagnosis and risk stratification of ACS is of great significance.[7]. Here, TNNI3 is linked to kidney failure.