The down-regulated DEGs in astrocytes from female E4FAD groups had most enriched pathways including responses to stress, regulation of cell killing and cell communication, etc. The female-specific LRP10 targets, which were derived as a union of the DEG signatures in the five brain cell subtypes in the female E3FAD and E4FAD mouse cohorts, were significantly enriched in the LRP10-centered, L-layer subnetworks of the female AD human brains (L = 4: adjusted p = 1.46E-06, fold enrichment (FE) = 1.38; L = 3: adjusted p = 1.21E-07, FE = 1.5; L = 2: adjusted p = 2.9E-04, FE = 1.8; Fig. 5E). This evidence concerns the gene LRP10 and Alzheimer disease.