When combining data of APOE4−/− and APOE4+/- subjects together, sex differences in lrp10 mRNA and LRP10 protein expression in AD samples become less evident (Supplemental Figs. 7A and 7B; APOE4+/- female AD versus APOE4+/- male AD: lrp10 mRNA p = 0.11; LRP10 protein p = 0.07). The gene discussed is APOE; the disease is Alzheimer disease.