Consistently in gene perturbation in vivo studies, up-regulation of LRP10 expression showed beneficial effects only in female E4FAD mice but not in male E4FAD mice or E3FAD mice (Fig. 4A), supporting the notion that LRP10 as a causal regulator for AD, impacts cognition performance and development of AD pathology in sex- and APOE genotype-specific manners. The gene discussed is APOE; the disease is Alzheimer disease.