The initial transcriptomic analysis of sex and APOE-genotype specific changes in EFAD mouse brains with or without LRP10 over-expression already indicates the distinct impacts of LRP10 on males and females as well as APOE genotypes in AD, validating the prediction of LRP10 as one key molecular regulator of sex difference in AD based upon a highly integrated network biology analysis of two large-scale multi-omics cohorts in AD. Here, APOE is linked to Alzheimer disease.