From qPCR analysis, lrp10 mRNA was significantly increased in female APOE4+/- AD brains (PHG) compared to female APOE4+/- controls with no significant differences in male APOE4+/- AD versus male APOE4+/- controls (Fig. 3C and Supplemental Table 12; APOE4+/- female AD versus APOE4+/- female control: log2FC -0.52 versus -2.17, p < 0.0001; APOE4+/- male AD versus APOE4+/- female control: log2FC 0.32 versus -2.17, p < 0.0001; APOE4+/- male AD versus APOE4+/- male control: log2FC 0.32 versus -0.68, p = 0.28). This evidence concerns the gene APOE and Alzheimer disease.