In our study, we demonstrated a significant increase of lrp10 mRNA levels and a dramatic reduction of LRP protein expression in APOE4+/- AD brains when compared to control counterparts (Fig. 3C and 3D) suggesting post-transcriptional and/or post-translational modifications such as a possibility of accelerated LRP10 protein degradation with compensatory up-regulation of transcriptional machinery. Here, APOE is linked to Alzheimer disease.