Through further verification, we found that knockdown of both SOGA1 and METTL16 reduced PDK4 mRNA and protein expression in CRC cells (Fig. 5M-O and Fig. S6B), whereas overexpression of METTL16 significantly upregulated PDK4 expression in CRC cells (Fig. S6C). The gene discussed is MTCL2; the disease is colorectal carcinoma.