Consistent with our results, circNEIL3 binds to IGF2BP3 and inhibits the ubiquitination of IGF2BP3 by E3 ubiquitin ligase HECTD4, thereby inhibiting the degradation of IGF2BP3 by the proteasome and promoting the proliferation and metastasis of glioma cells [37]. Here, IGF2BP3 is linked to central nervous system cancer.