NUCLEOLIN and neoplasm: Furthermore, abnormal proteins generated by tumor-related RNAs translation and proteins that participate and regulate related genes of tumors are also one of symbolic targets when cancers occur, such as RNA-binding protein (RBP) and nucleolin, etc. [64, 65] Tumor-related proteins are overexpressed in different cancer cell lines and endothelial cells, which the functional DNAs such as DNA aptamers and DNAzymes can recognize [66].