Guo et al.[56]showed that upregulating the expression of ERBB2 in nucleus pulposus cells is beneficial to their survival under nutrient-deficient conditions, while downregulation of ERBB2 leads to a decrease in the phosphorylation of Erk1/2, which in turn promotes the development of IDD [57]. Here, MAPK3 is linked to intervertebral disk degenerative disorder.