After adjusting for age, sex, BMI, smoking status, secondhand smoking, alcohol status, hypertension, dyslipidemia, hemoglobin, albumin, hemoglobin A1c, triglyceride, uric acid and serum creatinine, age, male gender, higher BMI, smoking and SHS exposure were five independent risk factors for the incident KSD (Table 3). The gene discussed is ALB; the disease is hypertensive disorder.