Subsequent genes related to circadian, neurotrophic, cell differentiation, serotonergic and glutamatergic signaling in mood episodes were also reported [63], such as NRG1, DOCK10, GLS, PRPS1, TMEM161B, GLO1, FANCF, HNRNPDL, CD47, OLFM1, SMAD7, and SLC6A4 for depression, while RLP3 and SLC6A4 for mania. Here, GLS is linked to major depressive disorder.