Different levels of hemoglobin concentrations in sepsis patients may be due to presenting conditions [4], nutritional deficiencies, inflammatory anemia [5–7], hemolysis [8, 9], loss of bloodletting, loss of gastrointestinal tract, transfusion expansion, fluid load resulting in hemodilution [10], decreased bone marrow response to erythropoietin [11], inhibition of erythropoietin production by pro-inflammatory cytokines [7, 12], response to drugs [13], inappropriate blood transfusion [14] and so on. Here, EPO is linked to Sepsis.