HGB < 120 g/L (HR = 2.211, 95% CI 1.548–3.158, P < 0.001), no-PR( HR = 1.883, 95% CI 1.289–2.751, P = 0.001), PVTT at baseline (HR = 2.732, 95% CI 1.859–4.015, P < 0.001), tumor size ≥ 5 cm ( HR = 2.202, 95% CI 1.533–3.163, P < 0.001), and tumor multiplicity (HR = 1.488, 95% CI 1.036–2.136, P = 0.031) were identified as independent risk factors for 1-year mortality by multivariate analysis (Table 2). This evidence concerns the gene CYGB and neoplasm.