However, since day 100 after transplantation, during 24 months follow-up, the prevalence of chronic GVHD in the recipient-donor group with KIR/HLA mismatch decreased by about 30%, which shows the improvement of the conditions of haplo-donors with mismatch structure compared to a KIR/HLA match group. Here, KIR3DL1 is linked to chronic graft versus host disease.