NK cells that have cytolytic action against tumor cells and virus-infected cells release proinflammatory cytokines (GM-CSF, IFN, TNF, CCL1, CCL2, CCL3, CCL4, CCL5, and CXCL8) including interferon (IFN), tumor necrosis factor (TNF), and chemokines (CCL1, CCL2, CCL3, CCL4, CCL5, and CXCL8). This evidence concerns the gene CXCL8 and neoplasm.