AGT and female reproductive system disorder: However, studies have also reported that aldosterone is involved in gynecological diseases due to metabolic alterations induced by the usage of hormonal contraceptives, PCOS, uterine fibroids and endometriosis, inflammation, and hypertension, which can result in an increase in the synthesis of angiotensinogen, activating all the RAAS and inducing the onset of sodium and water retention [110].