At the time of the fracture, the serum biochemical parameters of bone metabolism and cancer markers were 25-hydroxyvitamin D 32 ng/mL, total calcium 10.3 mg/dL, tartrate-resistant acid phosphatase 5b (TRACP-5b) 192 mU/dL, carcinoembryonic antigen (CEA) 66.3 ng/mL, and cancer antigen 15-3 (CA15-3) 109.7 U/mL. The gene discussed is ACP5; the disease is cancer.