Results showed that, compared to control conditions (siLUC), DIS3L2 KD also induced a significant decrease in the number of SW480 (72%) and HCT116 (93%) cells invading the lower chamber (Fig. 8B), indicating that depletion of DIS3L2 expression can disrupt the migratory and invasive properties of poorly differentiated CRC cells. The gene discussed is DIS3L2; the disease is colorectal carcinoma.