This is in agreement with our findings that depletion of DIS3L2 had little to no effect in the migratory behavior of well-differentiated HT-29 and Caco-2 cells, as well as of non-transformed NCM460 colonocytes, but nearly abolished the invasive abilities of poorly differentiated HCT116 and SW480 CRC cells. This evidence concerns the gene DIS3L2 and colorectal carcinoma.