Since another of the pathways enriched upon DIS3L2 depletion was “Regulation of the actin cytoskeleton”, and the DIS3L2 target, AZGP1, is known for its inhibitory effects in CRC cell migration [44], we next investigated whether the depletion or overexpression of DIS3L2 could alter the migratory behavior of our CRC cell lines. This evidence concerns the gene AZGP1 and colorectal carcinoma.