To further examine whether the pathogenic role of macrophage-derived Dectin-1 in Ang II-related renal fibrosis was achieved by increasing TGF-β1 expression, SV40 cells, a glomerulus myofibroblast-like cell line [27], were cultured with the supernatant from Dectin-1/Syk-inhibited macrophages. The gene discussed is SYK; the disease is renal fibrosis.