In our study, Ang II infusion markedly increased the levels of chemokines (CXCL1 and GCSF) and CXCR2 (the receptor of CXCL1) in the kidney, and Dectin-1 deficiency attenuated Ang II-induced renal dysfunction and renal fibrosis. The gene discussed is CXCR2; the disease is renal fibrosis.