According to the DEG expression analysis, FZD1, GPR37, IL10, LRRK2, MELK, MET, NOL3, P4HB, PDK1, PML, PYCR1, RACK1, SOD2, and TLR6 were highly expressed in ccRCC neoplastic tissues compared with peritumoral tissues (P < 0.05, Fig. 1B). This evidence concerns the gene TLR6 and nonpapillary renal cell carcinoma.