According to the DEG expression analysis, FZD1, GPR37, IL10, LRRK2, MELK, MET, NOL3, P4HB, PDK1, PML, PYCR1, RACK1, SOD2, and TLR6 were highly expressed in ccRCC neoplastic tissues compared with peritumoral tissues (P < 0.05, Fig. 1B). The gene discussed is MELK; the disease is nonpapillary renal cell carcinoma.