P4HB and nonpapillary renal cell carcinoma: According to the DEG expression analysis, FZD1, GPR37, IL10, LRRK2, MELK, MET, NOL3, P4HB, PDK1, PML, PYCR1, RACK1, SOD2, and TLR6 were highly expressed in ccRCC neoplastic tissues compared with peritumoral tissues (P < 0.05, Fig. 1B).