DLG4 and post-traumatic stress disorder: Chen et al. [44] found that downregulation of miR-153-3p in the hippocampus of rats could reduce apoptosis, increase neuronal dendritic spine density, and ultimately alleviate PTSD-like behaviors, possibly through the upregulation of sigma nonopioid intracellular receptor 1 (σ-1R) and PSD95 (postsynaptic density protein 95).