Nie et al. found that the downregulation of miR-142-5p, which could bind to FMRP in the hippocampus of SPS-exposure rats, resulted in NF-κB signaling pathway downregulation and alleviated PTSD-like behaviors by attenuating the neuroinflammation and increasing levels of synaptic proteins including PSD95 and synapsin-I (SYN1). The gene discussed is DLG4; the disease is post-traumatic stress disorder.