WFDC2 and inborn error of immunity: The GSEA analysis indicated that HE4 was negatively associated with E2F targets, G2M checkpoint, cell cycle, notch signaling and TGFβ signaling, while it was positively associated with immune related pathways (primary immunodeficiency, cytokine-cytokine receptor interaction) and oxidative phosphorylation (Fig. 2c, d).