According to the TNM stage of CRC patients, the levels of MARCKSL1 and CA125 were the highest in stage IV patients, the expression of MARCKSL1 showed a gradient increasing trend with increasing stage, and there was a significant difference between stage 0 + I + II and stage IV patients (P = 0.0225; Table 6, Fig. 5a). Here, MARCKSL1 is linked to colorectal carcinoma.