As for NEB, it was significantly downregulated in BRCA, HNSC, KICH, KIRP, and THCA; up-regulated in BLCA, CHOL, COAD, esophageal carcinoma (ESCA), liver hepatocellular carcinoma (LIHC), LUAD, LUSC, rectum adenocarcinoma (READ), stomach adenocarcinoma (STAD), and UCEC (P < 0.05; P < 0.01; P < 0.001). The gene discussed is NEB; the disease is colon adenocarcinoma.