They are also involved in KEGG pathways of protein digestion and absorption, ECM-receptor interaction, AGE-RAGE signaling pathway in diabetic complications, amoebiasis, focal adhesion, human papillomavirus infection, PI3K-Akt signaling pathway, Relaxin signaling pathway, small cell lung cancer, and platelet activation (Fig. 4B). This evidence concerns the gene PIK3CA and amebiasis.