While most genome-wide significant loci were previously associated with the cancer of interest18–22, we identified two novel loci in the single cancer GWAS in UKB (colorectal: rs143926630 at TULP4 on 6q25, P = 1.3 × 10−8; non-Hodgkin’s lymphoma: rs370149412 at MEF2B on 19p13, P = 4.7 × 10−8; Table 2 and Supplementary Fig. 2). Here, MEF2B is linked to cancer.