EDNRA and cancer: In addition, the combined meta-analysis identified three additional cancer risk variants (rs77753011 at RPH3A on 12q24, P = 5.5 × 10−15; rs36079339 at AIDA on 1q41, P = 3.9 × 10−10; rs2059904 at EDNRA on 4q31, P = 1.2 × 10−8; Table 2), of these two were pleiotropic associations.