PADI6 and breast cancer: Of these, the lead variant associated with breast cancer was correlated with the previously reported breast cancer risk variant, rs1924553 at PADI6 (r2 = 0.21 in Europeans; r2 = 0.42 in East Asians), but the previous study did not detect genome-wide significant associations at the PADI6 locus (P = 5.4 × 10−7)23.