We previously showed that increasing cells’ NADPH supply by 2-deoxyglucose (2-DG) treatment could prevent disulfide stress and cell death in glucose-starved, SLC7A11-overexpressing cancer cells (as a glucose analog, 2-DG can be shunted into the pentose phosphate pathway to generate NADPH)12. The gene discussed is SLC7A11; the disease is cancer.