To this end, we induced the expression of a genetically encoded, water-forming NADPH oxidase, triphosphopyridine nucleotide oxidase (TPNOX, which oxidizes cytosolic NADPH and therefore can be used as a genetic tool to increase the NADP+/NADPH ratio26) in either SLC7A11-low or-high cancer cells (Fig. 4k). Here, SLC7A11 is linked to cancer.