Coupled with apparent IFN-γ release by FcRH5 CAR-T cells upon stimulation with sIRTA2c alone, we hypothesize that sIRTA2c protein directly bound FcRH5 CAR-T cells and consequently interfered with the interactions between FcRH5 CAR-T cells and surface FcRH5 on MM cells within a short period of time. The gene discussed is FCRL5; the disease is Miyoshi myopathy.