USP25 and cancer: Ubiquitin-specific peptidase 25 (USP25) was initially identified to regulate anti-viral immunity through modulating TRAF proteins17 and later found to be associated with cancer development as it helps maintain the expression levels of Tankyrase, a poly-ADP-ribosyltransferase involved in Wnt signaling18, BCR-ABL in leukemia cells19, and EGFR through modulating its internalization and degradation20.