We aimed to study the association between mortality and characteristics of HIV severity (CD4 cell count and HIV viral load [VL]) and management (ART collection and time since first HIV evidence) as well as COVID‐19 vaccination status among adult (aged ≥15 years) PWH with a diagnosed SARS‐CoV‐2 infection in the Western Cape (WC) province of South Africa (SA), adjusted for demographic characteristics, comorbidities, area‐specific COVID‐19 hospital admission pressure, location and time period. The gene discussed is CD4; the disease is COVID-19.