In experimental studies, insulin sensitivity has been measured using the hyperinsulinemic clamp [24, 34, 63, 65, 68], the hepatic insulin sensitivity index [36], or a 75 g oral-glucose tolerance test (OGTT) [37] whereas insulin resistance has been measured via the homeostatic model assessment of insulin resistance (HOMA-IR) [62, 64, 66, 69]. The gene discussed is INS; the disease is Insulin resistance.