In addition to mouse MNs, we analyzed the expression of SRF and its cofactor MRTF-A in MNs of sporadic human ALS cases (Supplemental Figure 1 and Supplemental Table 1; supplemental material available online with this article; https://doi.org/10.1172/jci.insight.167694DS1). Here, SRF is linked to amyotrophic lateral sclerosis.