C1q+ MoMFs express many signature genes that play a crucial role in promoting clearance of necrotic tissues, but lack several lipid metabolism–associated signature genes (Cd36, Fabl4) that are observed in NAMs/LAMs from fatty liver disease and lack fibrosis-associated genes (Il1b, Cxcr4, Pdgfb, Vegfa, Hes1) that are observed in SAMs from cirrhotic livers. The gene discussed is HES1; the disease is fatty liver disease.