Previous studies have reported several populations of MoMFs, including lipid-associated macrophages (LAMs) (36), nonalcoholic steatohepatitis–associated macrophages (NAMs) (37), and scar-associated macrophages (SAMs) (38), that share certain characteristics, such as expression of Cd9, Trem2, and Osteopontin (Spp1). This evidence concerns the gene SPP1 and metabolic dysfunction-associated steatohepatitis.