GPT and digestive system neoplasm: To study the mechanisms by which necrotic lesions are resolved after acute liver injury, we utilized the ConA-induced immune-mediated acute liver-injury model, in which massive liver tissue damage, including hepatocyte necrosis, develops within 24 hours after ConA injection, resulting in rapid elevation of blood transaminase (ALT) (Supplemental Figure 1A; supplemental material available online with this article; https://doi.org/10.1172/JCI166954DS1) and large necrotic lesions (Figure 1A).