Interestingly, one of the human homologs of MML-1, carbohydrate response element binding protein (ChREBP/MondoB/MLXIPL/WBSCR14), maps within a deleted region in Williams-Beuren syndrome patients, which among other symptoms causes metabolic dysfunction, silent diabetes, and premature aging (Pober, 2010). Here, MLXIPL is linked to diabetes mellitus.