The analysis was accomplished using search engines including Pubmed/Medline, Web of Science and Scopus, and generic keywords such as FSHD, 4q35 locus, FSHD treatment, FSHD models or more specific terms like DUX4, 4q35 methylation, epigenetics. This evidence concerns the gene DUX4 and facioscapulohumeral muscular dystrophy.