REN and liver dysplastic nodule: PPARγ, the product of the PPARG gene, can be found in almost all type of cells in kidney both on vascular and parenchymal structures; this can explain the role that this gene plays in pathogenesis of DN, altering glomerular blood pressure due to a defected modulation in the production on renin in the juxtaglomerular cells and via reduction of the nitric oxide (NO) endothelial production [37, 38].