In the current work, we therefore, treated hypertensive, heterozygous Ren-2 transgenic rats (TGR), with high-output heart failure, induced by creating an aorto-caval fistula (ACF) with the sGC stimulator (BAY41-8543), which exhibits the same mode of action as riociguat and vericiguat (Sandner et al. 2021b). Here, SGCB is linked to heart failure.