Noteworthy the placebo treated rats with heart failure and the sGC stimulator-treated rats were excluded from the statistical analysis due to the low animal numbers; therefore, this analysis was conducted mainly to compare the effects of the treatments in sham operated animals (both TGR and HanSD) and between ACEi administered alone and combined treatment with ACEi and BAY41-8543. This evidence concerns the gene SGCB and heart failure.