Interestingly, the expression of p-AMPK was increased, and the levels of NF-κB and NLRP3 were decreased in the Abx+SAP group compared with the SAP-ALI group, which may be related to the reduced relative abundance of pathogenic bacteria following antibiotic gavage and warrants more in-depth study in the future. Here, NFKB1 is linked to acute respiratory distress syndrome.