Thus, it has been shown that Duloxetine also inhibits Organic Cation Transporter 2 (OCT2), a mechanism that is well-established to facilitate the uptake of Oxaliplatin into Dorsal Root Ganglion (DRG) neurons, thought to prevent Oxaliplatin-induced peripheral neuropathy (OIPN).35 While this study demonstrated that Duloxetine inhibits the uptake of Oxaliplatin into DRG neurons, Duloxetine has not been studied with reference to inhibiting transporters involved with Paclitaxel- and Bortezomib-induced peripheral neuropathy. This evidence concerns the gene SLC22A2 and peripheral neuropathy.