CRHBP and substance abuse: Other genes near the variant also showed involvement in brain development (ZBED3) (Ruan et al., 2021), in GABAergic interneurons in the prefrontal cortex (Ketchesin et al., 2017), hippocampal abnormalities (Ensink et al., 2021), depression, and other neuropsychiatric disorders such as substance abuse (CRHBP) (Curley et al., 2021; Kalin, 2018).