Studies have indicated that the development of postsurgical EHR of HCC is influenced by multiple clinicopathological features, including large tumor size, high AFP level, incomplete tumor capsule, portal vein tumor thrombus (PVTT)/MVI status, positive for HBsAg, high blood loss during surgery, as well as some molecular events (e.g., P53 mutations and CD44v3 expression).10, 11, 12, 13, 14. The gene discussed is TP53; the disease is neoplasm.