PITX2 and esophageal squamous cell carcinoma: Previous studies reported that elevated expression of PITX2 is associated with advanced progression and poor prognosis of lung adenocarcinoma [7,8], colorectal cancer [9,10], ovarian cancer[11], esophageal squamous cell carcinoma[12] and thyroid cancer [13,14], but few studies have reported the connection between PITX2 and pancreatic cancer.