The results that knockdown ofPITX2 inhibited the expressions of the mesenchymal marker vimentin and ECM protein a-SMA, as well as key factors of the Wnt/β-catenin signaling pathway, including LEF1, CTNNB1 and AXIN1, in PSCs shed light on the underlying mechanism of the inhibited progression of pancreatic cancer cells. The gene discussed is CTNNB1; the disease is pancreatic neoplasm.