The results that knockdown ofPITX2 inhibited the expressions of the mesenchymal marker vimentin and ECM protein a-SMA, as well as key factors of the Wnt/β-catenin signaling pathway, including LEF1, CTNNB1 and AXIN1, in PSCs shed light on the underlying mechanism of the inhibited progression of pancreatic cancer cells. Here, LEF1 is linked to pancreatic neoplasm.