Examination of the sympathetic and parasympathetic branches of the autonomic nervous system showed that fibres positive for tyrosine hydroxylase (TH, adrenergic), but not those positive for vesicular acetylcholine transporter (parasympathetic), are significantly denser in mutant p53 oral cavity squamous cell carcinomas (OCSCCs) than in wild-type p53 tumors[60]. This evidence concerns the gene TP53 and oral cavity squamous cell carcinoma.