ATIC and colorectal cancer: In colorectal cancer, p53 also promotes peroxisomal fatty acid β-oxidation, which increases cytosolic acetyl-CoA levels and acetylation of the enzyme 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase (ATIC), the enzyme that catalyzes the last two steps of purine synthesis[47].