The pathophysiological role of hepcidin in the development of anemia in cirrhosis is best explained by suppressor of mothers against decapentaplegic (SMAD) signaling pathway, wherein, IL-6 an inflammatory mediator binds to the IL-6 receptor and activates the Janus kinases signal transducer and activator of transcription protein-3 (JAK-STAT-3) pathway. Here, HAMP is linked to anemia (phenotype).