It has also been reported that intracerebroventricular administration of HMGB1 induces depression‐like behaviors, such as prolonged immobility time in tail suspension test (TST) or forced swimming test (FST) and decreased sucrose preference.7, 8, 9, 10, 11, 12, 13, 14. This evidence concerns the gene HMGB1 and major depressive disorder.