These findings that TSC EVs can alter recipient cell biology support those previously observed in mouse models of TSC, where Tsc1‐deficient neuronal progenitors could alter the phenotype of neighbouring genetically wild‐type neuronal cells via delivery of exosomes in a mouse model (Patel et al., 2016) and EVs from Tsc2‐deficient murine inner medullary collecting duct cell lines could modify the transcriptome of recipient cortical collecting duct cells (Kumar et al., 2021). The gene discussed is TSC2; the disease is tuberous sclerosis.