Of these, 21 proteins were enriched in TSC2‐ EVs, with IL‐6, MMPs, VEGF, Galectin‐3 previously associated with mTORC1‐driven tumours (Dodd et al., 2015; Klover et al., 2017; Lee et al., 2010; Shu et al., 2010; Young et al., 2013). This evidence concerns the gene VEGFA and neoplasm.