PTPRC and Sepsis: To explore the correlation of HLA-DRlowS100Ahigh with disease progression as well as sepsis-induced immunosuppression, we conducted a parallel, cross-species study on experimental model of sepsis using scRNA-seq data from our recently published resource, in which circulating CD45+ cells from mice undergoing sham surgery (0 h) or CLP operation at various intervals (8, 24, and 72 h) were isolated and subjected to scRNA-seq [23].