Nevertheless, anti-inflammatory cytokines and percentages of immunosuppressive Tregs were substantially augmented upon persistent septic exposure and compensatory increases in proinflammatory cytokines (IL-2 and IFN-γ) at 24 h after septic induction were completely abolished in the meantime, suggesting a shift from proinflammatory phase toward sepsis-induced immunosuppression at later stage of sepsis. This evidence concerns the gene IFNG and Sepsis.