Although the expression and distribution of PGE2-related enzymes and receptors in HD are poorly understood, in vivo studies in R6/1 HD model mice showed that antagonization of EP1 by SC-51089 ameliorated memory and motor deficits [117], while activation of EP2 by misoprostol ameliorated long-term memory deficits through up-regulation of brain-derived neurotrophic factor in the hippocampus [118]. The gene discussed is BDNF; the disease is Huntington disease.