PTGS2 and amyotrophic lateral sclerosis: Furthermore, TDP-43-deficient microglia induced neuronal death in a co-culture system, which was suppressed by the COX-2 inhibitor celecoxib [93], suggesting that the glial cells with genetic variant associated with ALS, not limited to SOD1G93A, contribute to neurodegeneration in ALS through elevated basal levels of PGE2.