Furthermore, TDP-43-deficient microglia induced neuronal death in a co-culture system, which was suppressed by the COX-2 inhibitor celecoxib [93], suggesting that the glial cells with genetic variant associated with ALS, not limited to SOD1G93A, contribute to neurodegeneration in ALS through elevated basal levels of PGE2. The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.