We assessed relationships between serum biomarkers of cardiac stress and subsequent subclinical CAD in a 2-year prospective cohort of older persons living with HIV (PLWH) and HIV-uninfected controls in Uganda, hypothesizing that some markers of myocardial stress, specifically NT-proBNP, would be associated with subclinical coronary atherosclerosis. This evidence concerns the gene NPPB and coronary artery disorder.