TCF4 and neoplasm: In summary, we suggested that the TP53/TCF4 axis could play an important role in the process of oridonin-induced Endoplasmic Reticulum stress and that oridonin could induce continuous Endoplasmic Reticulum stress through the regulation of the TP53/TCF4 axis by increasing ROS generation and disrupting Ca2+ homeostasis, thus inhibiting tumor progression.