In addition, the contribution of Notch3 in mouse (GSE112393) and human (GSE142585) (See Additional File 2) testicular interstitial cells might reflect the contribution of Notch3 in the blood vessels since this gene is involved in a hereditary arteriopathy named cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) [34]. This evidence concerns the gene NOTCH3 and CADASIL.