APOE and tauopathy: Erdr1, a stress-induced cell survival factor, was downregulated in APOE4 mice relative to APOE3 and APOE2 mice while Eps8l1, a tauopathy-related Bin1-responsive gene, was downregulated in APOE3 mice relative to APOE4 and APOE2 mice [51, 52].