MAPT and Alzheimer disease: Immunostaining with pan Aβ and AT8 antibodies demonstrated that AD patients of both E4 and non-E4 genotypes showed the expected robust patterns of Aβ deposits and intracellular tau tangles relative to age-matched controls (****p < 0.0001 for Aβ; **p < 0.01 for phospho-tau) (Fig. 7A, B).