Notable genes that have been reported to be part of the APOE-associated pathogenic signature in AD, Trem2 (↑3.7x, p = 1.46E−22) and Clec7A (↑36.2x, p = 3.1E−25), were upregulated in PS/E4H mice compared to E4H mice. Here, TREM2 is linked to Alzheimer disease.