demonstrated that α-Actinin-4 is a selective transcriptional co-activator of NF-κB to mediate the expression of matrix metalloproteinase genes MMP-3 and MMP-1 without affecting the expression of other NF-κB target genes, including BAX, TNC, FGF8, PTGS2, ICAM1 and FN1 in cancer cells [35]. This evidence concerns the gene NFKB1 and cancer.